Playing guitar hurts, especially at the beginning. If you’re playing piano and you play for a few hours, your wrists will hurt only if your technique is wrong. If you are playing violin and you play for several hours, then you might be a bit sore from standing the same way for a few hours, but you’d be sore from standing for a few hours anyway. If you play guitar for a few hours and you haven’t played in a long time, then you will discover things that you might not want to know, and that is calluses. This doesn’t mater if you’re working with guitar bass parts or guitar parts acoustic, you will end up with really painful calluses for the first couple weeks.
You might also end up with hand cramps. Hand cramps usually happen if you are playing bar chords for a long time and have to put a lot of pressure on the neck of the guitar. Dealing with things like that is never any fun, and if you are the sort of person who doesn’t want to have these things on your fingers, then you need to figure out what you’re dealing with. That will help you out quite a bit if you are willing to play around with ideas. One guitar accessory that has not been invented is callus help.
If you can get yourself some rubber things that will project you from getting a callus, you may discover that you will be able to play guitar much longer, but if someone surprises you with a guitar and you haven’t got your callus protection on, then you won’t be able to play as well or as long. If you just deal with the calluses for awhile, you will be much better off. That will make life much easier to deal with when you are playing guitar and getting it working the first couple times around.